Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
نویسندگان
چکیده
منابع مشابه
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and the mitochondrial permeability transition pore on ER stress-induced MOMP and subsequent cell death. Induction of ER stress leads to upregulation of several genes such as Grp78, ...
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ژورنال
عنوان ژورنال: International Journal of Cell Biology
سال: 2010
ISSN: 1687-8876,1687-8884
DOI: 10.1155/2010/170215